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Article

Crohn's Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function.

Nature communications - 15 Mar 2025

Li Yingcong, Ascui Gabriel, Dicker Martina, Riffelmacher Thomas, Chandra Vivek, Schmiedel Benjamin, Chou Ting-Fang, Vijayanand Pandurangan, Kronenberg Mitchell

Abstract excerpt

Genome wide association studies (GWAS) identify many risks for Crohn's disease (CD), including a site near the metabolism gene laccase domain containing 1 (LACC1). We previously found this site near LACC1 was associated with decreased LACC1 expression in T lymphocytes, yet the mechanism affecting gene expression and its links to T cell function and inflammatory disease were unknown. Here we identify variants in...

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Share to CD4-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 40089498
DOI: 10.1038/s41467-025-57744-3
PMCID: PMC11910630

Genes

LACC1
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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