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Article

Differences in DNA Methylation and Functional Expression in Lactase Persistent and Non-persistent Individuals.

Scientific reports - 4 Apr 2018

Leseva Milena N, Grand Richard J, Klett Hagen, Boerries Melanie, Busch Hauke, Binder Alexandra M, Michels Karin B

Abstract excerpt

In humans the expression of lactase changes during post-natal development, leading to phenotypes known as lactase persistence and non-persistence. Polymorphisms within the lactase gene (LCT) enhancer, in particular the -13910C > T, but also others, are linked to these phenotypes. We were interested in identifying dynamic mediators of LCT regulation, beyond the genotype at -13910C > T. To this end, we investigated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29618745
DOI: 10.1038/s41598-018-23957-4
PMCID: PMC5884863

Genes

LCT
CDX2
GATA4
GATA6

Provenance

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