Article
C13orf31 (FAMIN) is a central regulator of immunometabolic function.
Nature immunology - 1 Sept 2016
Cader M Zaeem, Boroviak Katharina, Zhang Qifeng, Assadi Ghazaleh, Kempster Sarah L, Sewell Gavin W, Saveljeva Svetlana, Ashcroft Jonathan W, Clare Simon, Mukhopadhyay Subhankar, Brown Karen P, Tschurtschenthaler Markus, Raine Tim, Doe Brendan, Chilvers Edwin R, Griffin Jules L, Kaneider Nicole C, Floto R Andres, D'Amato Mauro, Bradley Allan, Wakelam Michael J O, Dougan Gordon, Kaser Arthur
Abstract excerpt
Single-nucleotide variations in C13orf31 (LACC1) that encode p.C284R and p.I254V in a protein of unknown function (called 'FAMIN' here) are associated with increased risk for systemic juvenile idiopathic arthritis, leprosy and Crohn's disease. Here we set out to identify the biological mechanism affected by these coding variations. FAMIN formed a complex with fatty acid synthase (FASN) on peroxisomes and promoted...
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