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Article

Association of Alzheimer's disease genetic risk with age-dependent changes in plasma amyloid-β42:40 in Veterans.

Journal of Alzheimer's disease : JAD - 1 Apr 2025

Pierce Meghan E, Logue Mark, Sherva Richard, Miller Mark, Huber Bertrand R, Milberg William, Hayes Jasmeet P

Abstract excerpt

BackgroundIdentifying biomarkers of Alzheimer's disease (AD) is critical for early diagnosis and AD risk assessment.ObjectiveWe examined the hypothesis that the plasma amyloid-β 42 and 40 (Aβ42:40) ratio has a curvilinear relationship with age among individuals who are at higher genetic risk for AD.MethodsThis study investigated the relationship between plasma amyloid-β 42 and 40 (Aβ42:40) ratio and age in 315...

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PMID: 40084666
DOI: 10.1177/13872877251321183

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