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Metabolic Profiling of Cognitive Aging in Midlife

5 Nov 2020

Abstract excerpt

Alzheimer's dementia (AD) begins many years before its clinical symptoms. Metabolic dysfunction represents a core feature of AD and cognitive impairment, but few metabolomic studies have focused on cognitive aging in midlife. Using an untargeted metabolomics approach, we identified metabolic predictors of cognitive aging in midlife using fasting plasma sample from 30 middle-aged (mean age 57.2), male-male twin...

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PMID: 33250761
DOI: 10.3389/fnagi.2020.555850

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