Article
Plasma amyloid-β ratios in autosomal dominant Alzheimer's disease: the influence of genotype.
Brain : a journal of neurology - 29 Nov 2021
O'Connor Antoinette, Pannee Josef, Poole Teresa, Arber Charles, Portelius Erik, Swift Imogen J, Heslegrave Amanda J, Abel Emily, Willumsen Nanet, Rice Helen, Weston Philip S J, Ryan Natalie S, Polke James M, Nicholas Jennifer M, Mead Simon, Wray Selina, Chávez-Gutiérrez Lucía, Frost Chris, Blennow Kaj, Zetterberg Henrik, Fox Nick C
Abstract excerpt
In vitro studies of autosomal dominant Alzheimer's disease implicate longer amyloid-β peptides in disease pathogenesis; however, less is known about the behaviour of these mutations in vivo. In this cross-sectional cohort study, we used liquid chromatography-tandem mass spectrometry to analyse 66 plasma samples from individuals who were at risk of inheriting a mutation or were symptomatic. We tested for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.