Article
Whole exome sequence-based association analyses of plasma amyloid-β in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study.
PloS one - 1 Jan 2017
Simino Jeannette, Wang Zhiying, Bressler Jan, Chouraki Vincent, Yang Qiong, Younkin Steven G, Seshadri Sudha, Fornage Myriam, Boerwinkle Eric, Mosley Thomas H
Abstract excerpt
OBJECTIVE: We performed single-variant and gene-based association analyses of plasma amyloid-β (aβ) concentrations using whole exome sequence from 1,414 African and European Americans. Our goal was to identify genes that influence plasma aβ42 concentrations and aβ42:aβ40 ratios in late middle age (mean = 59 years), old age (mean = 77 years), or change over time (mean = 18 years). METHODS: Plasma aβ measures were...
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