Article
Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease.
Neurology - 2 Oct 2018
McDade Eric, Wang Guoqiao, Gordon Brian A, Hassenstab Jason, Benzinger Tammie L S, Buckles Virginia, Fagan Anne M, Holtzman David M, Cairns Nigel J, Goate Alison M, Marcus Daniel S, Morris John C, Paumier Katrina, Xiong Chengjie, Allegri Ricardo, Berman Sarah B, Klunk William, Noble James, Ringman John, Ghetti Bernardino, Farlow Martin, Sperling Reisa A, Chhatwal Jasmeer, Salloway Stephen, Graff-Radford Neill R, Schofield Peter R, Masters Colin, Rossor Martin N, Fox Nick C, Levin Johannes, Jucker Mathias, Bateman Randall J
Abstract excerpt
OBJECTIVE: To assess the onset, sequence, and rate of progression of comprehensive biomarker and clinical measures across the spectrum of Alzheimer disease (AD) using the Dominantly Inherited Alzheimer Network (DIAN) study and compare these to cross-sectional estimates. METHODS: We conducted longitudinal clinical, cognitive, CSF, and neuroimaging assessments (mean of 2.7 [±1.1] visits) in 217 DIAN participants....
Topics
- Adult
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Biomarkers
- Brain
- Cognition
- Cross-Sectional Studies