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Article

Leukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system.

The Journal of experimental medicine - 2 Jun 2025

Jang Geunhyo, Park Rosa, Esteva Eduardo, Hsu Pei-Feng, Feng Jue, Upadhaya Samik, Sawai Catherine M, Aifantis Iannis, Fooksman David R, Reizis Boris

Abstract excerpt

Leukemia-driving mutations are thought to arise in hematopoietic stem cells (HSC), yet the natural history of their spread is poorly understood. We genetically induced mutations within endogenous murine HSC and traced them in unmanipulated animals. In contrast to mutations associated with clonal hematopoiesis (such as Tet2 deletion), the leukemogenic KrasG12D mutation dramatically accelerated HSC contribution to...

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Identifiers

PMID: 40072317
DOI: 10.1084/jem.20240587
PMCID: PMC11899982

Genes

CXCR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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