Article
Oncogenic KrasG12D Activation in the Nonhematopoietic Bone Marrow Microenvironment Causes Myelodysplastic Syndrome in Mice.
Molecular cancer research : MCR - 1 Sept 2021
Osswald Lena, Hamarsheh Shaima'a, Uhl Franziska Maria, Andrieux Geoffroy, Klein Claudius, Dierks Christine, Duquesne Sandra, Braun Lukas M, Schmitt-Graeff Annette, Duyster Justus, Boerries Melanie, Brummer Tilman, Zeiser Robert
Abstract excerpt
The bone marrow microenvironment (BMME) is key player in regulation and maintenance of hematopoiesis. Oncogenic RAS mutations, causing constitutive activation of multiple tumor-promoting pathways, are frequently found in human cancer. So far in hematologic malignancies, RAS mutations have only been reported to occur in hematopoietic cells. In this study, we investigated the effect of oncogenic Kras expression in...
Topics
- Animals
- Bone Marrow Cells
- Cell Differentiation
- Cell Proliferation
- Cell Transformation, Neoplastic
- Hematopoietic Stem Cells
- Humans
- Mice
- Mice, Inbred C57BL
- Mutation
- Myelodysplastic Syndromes
- Phenotype