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Article

Wild-type KRAS inhibits oncogenic KRAS-induced T-ALL in mice.

Leukemia - 1 May 2015

Staffas A, Karlsson C, Persson M, Palmqvist L, Bergo M O

Abstract excerpt

The role of hyperactive RAS signaling is well established in myeloid malignancies but less clear in T-cell malignancies. The Kras2(LSL)Mx1-Cre (KM) mouse model expresses endogenous KRAS(G12D) in hematopoietic cells and is widely used to study mechanisms and treatment of myeloproliferative neoplasms (MPN). The model displays an intriguing shift from MPN to acute T-cell leukemia (T-ALL) after transplantation to...

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Source

Identifiers

PMID: 25371176
DOI: 10.1038/leu.2014.315

Genes

KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Wild-type KRAS inhibits oncogenic KRAS-induced T-ALL in mice.PMID 25371176Read ↗

Oncogenic Kras Initiates Leukemia in Hematopoietic Stem CellsSemantic proximity Read ↗

Pdx1 expression in hematopoietic cells activates Kras-mutation to drive leukemia in KC (Pdx1-Cre; LSL-KrasG12D/+) mice.Semantic proximity Read ↗

Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.Semantic proximity Read ↗

Somatic activation of oncogenic <i>Kras</i> in hematopoietic cells initiates a rapidly fatal myeloproliferative disorderSemantic proximity Read ↗

Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation.Semantic proximity Read ↗

Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation.Semantic proximity Read ↗

Wild-type Kras expands and exhausts hematopoietic stem cells.Semantic proximity Read ↗

Loss of Dnmt3a and endogenous Kras(G12D/+) cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis.Semantic proximity Read ↗

Leukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system.Semantic proximity Read ↗

Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo.Semantic proximity Read ↗

Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.Semantic proximity Read ↗

Oncogenic KrasG12D Activation in the Nonhematopoietic Bone Marrow Microenvironment Causes Myelodysplastic Syndrome in Mice.Semantic proximity Read ↗

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