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Article

Wild-type Kras expands and exhausts hematopoietic stem cells.

JCI insight - 7 Jun 2018

Sasine Joshua P, Himburg Heather A, Termini Christina M, Roos Martina, Tran Evelyn, Zhao Liman, Kan Jenny, Li Michelle, Zhang Yurun, de Barros Stéphanie C, Rao Dinesh S, Counter Christopher M, Chute John P

Abstract excerpt

Oncogenic Kras expression specifically in hematopoietic stem cells (HSCs) induces a rapidly fatal myeloproliferative neoplasm in mice, suggesting that Kras signaling plays a dominant role in normal hematopoiesis. However, such a conclusion is based on expression of an oncogenic version of Kras. Hence, we sought to determine the effect of simply increasing the amount of endogenous wild-type Kras on HSC fate. To...

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Identifiers

PMID: 29875320
DOI: 10.1172/jci.insight.98197
PMCID: PMC6124423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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