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Nonrepair functions of DNA mismatch repair proteins: new avenues for precision oncology

29 Oct 2024

Abstract excerpt

DNA damage repair (DDR) proteins are well recognized as guardians of the genome that are frequently lost during malignant transformation of normal cells across cancer types. To date, their tumor suppressor functions have been generally regarded as a consequence of their roles in maintaining genomic stability: more genomic instability increases the risk of oncogenic transformation events. However, recent...

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PMID: 39490324
DOI: 10.1016/j.trecan.2024.10.001

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