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Deficient Mismatch Repair and Microsatellite Instability in Solid Tumors

6 May 2025

Abstract excerpt

The integrity of the genome is maintained by mismatch repair (MMR) proteins that recognize and repair base mismatches and insertion/deletion errors generated during DNA replication and recombination. A defective MMR system results in genome-wide instability and the progressive accumulation of mutations. Tumors exhibiting deficient MMR (dMMR) and/or high levels of microsatellite instability (termed "microsatellite...

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PMID: 40362635
DOI: 10.3390/ijms26094394

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