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Article

Increased exacerbations and hospitalizations among PIMZ compared to PIMM individuals: an electronic health record analysis.

Respiratory research - 11 Jul 2025

Tejwani Vickram, Wang Yifan, Tremblay Lauren Munoz, Azzato Elizabeth, Baldomero Arianne K, Wendt Christine, Attaway Amy, Bowler Russell, Hatipoglu Umur, Hutton Rebecca, Strange Charlie, Wang Xiaofeng, Ortega Victor E, Zein Joe, Stoller James K

Abstract excerpt

BACKGROUND: The best described endotype of COPD is alpha-1 antitrypsin (AAT) deficiency, due to a genetic abnormality in the SERPINA1 gene. Common deficient PI variants are the Z and S variants. Homozygotes for the Z allele (PI*ZZ individuals) carry the genotype most commonly associated with severe AAT deficiency (AATD), but a highly prevalent endotype is the heterozygous state (PI*MZ individuals). The effect of...

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Identifiers

PMID: 40646587
DOI: 10.1186/s12931-025-03322-6
PMCID: PMC12247371

Genes

SERPINA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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