Article
Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes.
American journal of respiratory and critical care medicine - 15 Feb 2014
Molloy Kevin, Hersh Craig P, Morris Valerie B, Carroll Tomás P, O'Connor Catherine A, Lasky-Su Jessica A, Greene Catherine M, O'Neill Shane J, Silverman Edwin K, McElvaney Noel G
Abstract excerpt
RATIONALE: Severe α1-antitrypsin deficiency (typically PiZZ homozygosity) is associated with a significantly increased risk of airflow obstruction and emphysema but the risk of chronic obstructive pulmonary disease (COPD) in PiMZ heterozygotes remains uncertain. OBJECTIVES: This was a family-based study to determine the risk of COPD in PiMZ individuals. METHODS: We compared 99 PiMM and 89 PiMZ nonindex subjects...
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