Article
Comparison among populations with severe and intermediate alpha1-antitrypsin deficiency and chronic obstructive pulmonary disease.
Minerva medica - 1 Feb 2024
Piloni Davide, Ottaviani Stefania, Saderi Laura, Corda Luciano, Baderna Paolo, Barzon Valentina, Balderacchi Alice M, Seebacher Christine, Balbi Bruno, Albicini Federica, Corino Alessandra, Mennitti Maria C, Tirelli Claudio, Spreafico Fabio, Bosio Matteo, Mariani Francesca, Sotgiu Giovanni, Corsico Angelo G, Ferrarotti Ilaria
Abstract excerpt
BACKGROUND: Severe alpha1-antitrypsin (AAT) deficiency (AATD) is associated with a high risk of airflow obstruction and emphysema. The risk of lung disease in those with intermediate AAT deficiency is unclear. Our aims were to compare pulmonary function, time of onset of symptoms, and indicators of quality of life among patients with severe AATD (PI*ZZ), patients with intermediate AATD (PI*MZ) from the Italian...
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