Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Change in lung function and morbidity from chronic obstructive pulmonary disease in alpha1-antitrypsin MZ heterozygotes: A longitudinal study of the general population.

Annals of internal medicine - 19 Feb 2002

Dahl Morten, Tybjaerg-Hansen Anne, Lange Peter, Vestbo Jørgen, Nordestgaard Børge G

Abstract excerpt

BACKGROUND: A deteriorating effect of severe alpha(1)-antitrypsin deficiency (ZZ genotype) on lung function is well known, whereas the role of intermediate deficiency (MZ genotype) remains uncertain. OBJECTIVE: To test the hypothesis that MZ intermediate alpha(1)-antitrypsin deficiency affects pulmonary function and disease. DESIGN: Population-based cohort study with 21-year follow-up. SETTING: Copenhagen,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha 1-Antitrypsin Deficiency
Share to Blood Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystic Fibrosis Transmembrane Conductance Regulator

Share to Denmark

Share to Forced Expiratory Volume

Share to Hospitalization

Share to Pulmonary Disease, Chronic Obstructive

Share to Spirometry

Source

Identifiers

PMID: 11848724
DOI: 10.7326/0003-4819-136-4-200202190-00006

Genes

FEV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Change in lung function and morbidity from chronic obstructive pulmonary disease in alpha1-antitrypsin MZ heterozygotes: A longitudinal study of the general population.PMID 11848724Read ↗

Molecular diagnosis of intermediate and severe alpha(1)-antitrypsin deficiency: MZ individuals with chronic obstructive pulmonary disease may have lower lung function than MM individuals.Semantic proximity Read ↗

Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease.Semantic proximity Read ↗

α₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts.Semantic proximity Read ↗

SZ alpha-1 antitrypsin deficiency and pulmonary disease: more like MZ, not like ZZ.Semantic proximity Read ↗

Z variant heterozygosity in alpha-1 antitrypsin deficiency: disease risk and treatment implications.Semantic proximity Read ↗

Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes.Semantic proximity Read ↗

COPD in individuals with the PiMZ alpha-1 antitrypsin genotype.Semantic proximity Read ↗

Comparison among populations with severe and intermediate alpha1-antitrypsin deficiency and chronic obstructive pulmonary disease.Semantic proximity Read ↗

Longitudinal Outcomes in Pi*MZ Alpha-1 Antitrypsin-Deficient Individuals with Tobacco Smoking History from the SPIROMICS Cohort.Semantic proximity Read ↗

Clarifying the Risk of Lung Disease in SZ Alpha-1 Antitrypsin Deficiency.Semantic proximity Read ↗

Rare alpha-1-antitrypsin variants: are they really so rare?Semantic proximity Read ↗

Risk of Lung Disease in PI MZ Heterozygotes. Current Status and Future Research Directions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.