Article
α₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts.
Chest - 1 Nov 2010
Sørheim Inga-Cecilie, Bakke Per, Gulsvik Amund, Pillai Sreekumar G, Johannessen Ane, Gaarder Per I, Campbell Edward J, Agustí Alvar, Calverley Peter M A, Donner Claudio F, Make Barry J, Rennard Stephen I, Vestbo Jørgen, Wouters Emiel F M, Paré Peter D, Levy Robert D, Coxson Harvey O, Lomas David A, Hersh Craig P, Silverman Edwin K
Abstract excerpt
BACKGROUND: Severe α₁-antitrypsin deficiency is a known genetic risk factor for COPD. Heterozygous (protease inhibitor [PI] MZ) individuals have moderately reduced serum levels of α₁-antitrypsin, but whether they have an increased risk of COPD is uncertain. METHODS: We compared PI MZ and PI MM individuals in two large populations: a case-control study from Norway (n = 1,669) and a multicenter family-based study...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.