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Article

Alpha-1 Antitrypsin PiMZ Genotype Is Associated with Chronic Obstructive Pulmonary Disease in Two Racial Groups.

Annals of the American Thoracic Society - 1 Aug 2017

Foreman Marilyn G, Wilson Carla, DeMeo Dawn L, Hersh Craig P, Beaty Terri H, Cho Michael H, Ziniti John, Curran-Everett Douglas, Criner Gerard, Hokanson John E, Brantly Mark, Rouhani Farshid N, Sandhaus Robert A, Crapo James D, Silverman Edwin K

Abstract excerpt

RATIONALE: Alpha-1 antitrypsin deficiency, caused primarily by homozygosity for the Z allele of the SERPINA1 gene, is a well-established genetic cause of chronic obstructive pulmonary disease (COPD). Whether the heterozygous PiMZ genotype for alpha-1 antitrypsin confers increased risk for COPD has been debated. OBJECTIVES: We analyzed 8,271 subjects in the Genetic Epidemiology of COPD (COPDGene) Study,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28380308
DOI: 10.1513/AnnalsATS.201611-838OC
PMCID: PMC5566271

Genes

SERPINA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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