Article
Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease.
American journal of respiratory and critical care medicine - 1 Feb 2022
Ghosh Auyon J, Hobbs Brian D, Moll Matthew, Saferali Aabida, Boueiz Adel, Yun Jeong H, Sciurba Frank, Barwick Lucas, Limper Andrew H, Flaherty Kevin, Criner Gerard, Brown Kevin K, Wise Robert, Martinez Fernando J, Lomas David, Castaldi Peter J, Carey Vincent J, DeMeo Dawn L, Cho Michael H, Silverman Edwin K, Hersh Craig P
Abstract excerpt
Rationale: Multiple studies have demonstrated an increased risk of chronic obstructive pulmonary disease (COPD) in heterozygous carriers of the AAT (alpha-1 antitrypsin) Z allele. However, it is not known if MZ subjects with COPD are phenotypically different from noncarriers (MM genotype) with COPD. Objectives: To assess if MZ subjects with COPD have different clinical features compared with MM subjects with...
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