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Article

Neandertal introgression and accumulation of hypomorphic mutations in the neuropeptide S (NPS) system promote attenuated functionality.

Peptides - 1 Apr 2021

Reinscheid Rainer K, Mafessoni Fabrizio, Lüttjohann Annika, Jüngling Kay, Pape Hans-Christian, Schulz Stefan

Abstract excerpt

The neuropeptide S (NPS) system plays an important role in fear and fear memory processing but has also been associated with allergic and inflammatory diseases. Genes for NPS and its receptor NPSR1 are found in all tetrapods. Compared to non-human primates, several non-synonymous single-nucleotide polymorphisms (SNPs) occur in both human genes that collectively result in functional attenuation, suggesting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33556445
DOI: 10.1016/j.peptides.2021.170506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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