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Article

Combined Mutational and Spectroscopic Study on the Calcium-Related Kinetic Effects on the VirChR1 Photocycle.

The journal of physical chemistry. B - 20 Mar 2025

Lamm Gerrit H U, Zabelskii Dmitrii, Balandin Taras, Gordeliy Valentin, Wachtveitl Josef

Abstract excerpt

The viral rhodopsin 1 subfamily consists of microbial rhodopsins, such as VirChR1, with a light-gated cation channeling functionality, which is inhibited by calcium. For VirChR1, S14, E54, and N225 have been proposed as key residues for calcium binding. They form a highly conserved SEN-triad in channelrhodopsins near the functionally important central gate. Here, we present a time-resolved UV/vis spectroscopic...

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Identifiers

PMID: 40063977
DOI: 10.1021/acs.jpcb.4c08416
PMCID: PMC11931529

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