Article
The high-light-sensitivity mechanism and optogenetic properties of the bacteriorhodopsin-like channelrhodopsin GtCCR4.
Molecular cell - 19 Sept 2024
Tanaka Tatsuki, Hososhima Shoko, Yamashita Yo, Sugimoto Teppei, Nakamura Toshiki, Shigemura Shunta, Iida Wataru, Sano Fumiya K, Oda Kazumasa, Uchihashi Takayuki, Katayama Kota, Furutani Yuji, Tsunoda Satoshi P, Shihoya Wataru, Kandori Hideki, Nureki Osamu
Abstract excerpt
Channelrhodopsins are microbial light-gated ion channels that can control the firing of neurons in response to light. Among several cation channelrhodopsins identified in Guillardia theta (GtCCRs), GtCCR4 has higher light sensitivity than typical channelrhodopsins. Furthermore, GtCCR4 shows superior properties as an optogenetic tool, such as minimal desensitization. Our structural analyses of GtCCR2 and GtCCR4...
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