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Article

Bioinformatic and mutational analysis of channelrhodopsin-2 protein cation-conducting pathway.

The Journal of biological chemistry - 10 Feb 2012

Plazzo Anna Pia, De Franceschi Nicola, Da Broi Francesca, Zonta Francesco, Sanasi Maria Federica, Filippini Francesco, Mongillo Marco

Abstract excerpt

Channelrhodopsin-2 (ChR2) is a light-gated cation channel widely used as a biotechnological tool to control membrane depolarization in various cell types and tissues. Although several ChR2 variants with modified properties have been generated, the structural determinants of the protein function are largely unresolved. We used bioinformatic modeling of the ChR2 structure to identify the putative cationic pathway...

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Identifiers

PMID: 22139833
DOI: 10.1074/jbc.M111.326207
PMCID: PMC3281600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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