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Article

Channel Gating in Kalium Channelrhodopsin Slow Mutants.

Journal of molecular biology - 1 Mar 2024

Sineshchekov Oleg A, Govorunova Elena G, Li Hai, Wang Yumei, Spudich John L

Abstract excerpt

Kalium channelrhodopsin 1 from Hyphochytrium catenoides (HcKCR1) is the first discovered natural light-gated ion channel that shows higher selectivity to K+ than to Na+ and therefore is used to silence neurons with light (optogenetics). Replacement of the conserved cysteine residue in the transmembrane helix 3 (Cys110) with alanine or threonine results in a >1,000-fold decrease in the channel closing rate. The...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 37802216
DOI: 10.1016/j.jmb.2023.168298
PMCID: PMC10932829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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