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Pathogenic germline variants among patients with ovarian cancer by self-reported ancestry: A commercial laboratory collaborative research registry study.

Gynecologic oncology - 1 Jan 2026

Aryasomayajula Chinmayi, Johnson Caitlin R, Francoeur Alex A, Sia Tiffany Y, Darcy Kathleen M, Tian Chunqiao, Kapp Daniel S, Chan John K, Liu Ying L

Abstract excerpt

OBJECTIVE: Ovarian cancer (OC) is highly lethal, and ∼15-20 % of cases occur in patients with germline pathogenic variants (gPVs) in BRCA1/2 and other genes related to homologous recombination (HR) and mismatch repair. We sought to characterize the germline landscape of patients with OC by self-identified ancestry. METHODS: Patients with epithelial OC who received germline testing were identified from the...

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PMID: 41232208
DOI: 10.1016/j.ygyno.2025.11.003

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BRCA1

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