Article
Glioma mutational signatures associated with haloalkane exposure are enriched in firefighters.
Cancer - 15 Mar 2025
Cannataro Vincent L, Bracci Paige M, Taylor Jennie W, McCoy Lucie, Rice Terri, Hansen Helen M, Heffernan Anne E, Wiemels Joseph, Wiencke John, Wrensch Margaret, Claus Elizabeth B
Abstract excerpt
BACKGROUND: Glioma is the most common malignant primary brain tumor and is associated with significant morbidity and mortality. Modifiable risk factors remain unidentified. New advances in exposure assessment, genomic analyses, and statistical techniques permit more accurate evaluation of glioma risk associated with exogenous occupational or environmental exposures. METHODS: By using whole-exome sequencing data...
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- Humans
- Firefighters
- Glioma
- Occupational Exposure
- Male
- Female