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Article

Mutational Analysis of Ionizing Radiation Induced Neoplasms.

Cell reports - 22 Sept 2015

Sherborne Amy L, Davidson Philip R, Yu Katharine, Nakamura Alice O, Rashid Mamunur, Nakamura Jean L

Abstract excerpt

Ionizing radiation (IR) is a mutagen that promotes tumorigenesis in multiple exposure contexts. One severe consequence of IR is the development of second malignant neoplasms (SMNs), a radiotherapy-associated complication in survivors of cancers, particularly pediatric cancers. SMN genomes are poorly characterized, and the influence of genetic background on genotoxin-induced mutations has not been examined. Using...

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Identifiers

PMID: 26344771
DOI: 10.1016/j.celrep.2015.08.015
PMCID: PMC6810600

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