Article
Mutational signature analysis of chronic lymphocytic leukemia uncovering genomic patterns and prognostic implications.
American journal of clinical pathology - 4 Oct 2025
AlJabban Ali, Azevedo Roberta S, Antel Katherine, Arnette Allison, Cohen Elizabeth F, Meredith David M, Murakami Mark A, Sholl Lynette M, Tolstorukov Michael Y, Tsai Harrison K, Tsai Jonathan M, Zemmour David, Lindeman Neal I, Garcia Elizabeth, Brown Jennifer R, Kim Annette S
Abstract excerpt
OBJECTIVE: To identify the mutational signature(s) for patients with diagnosed chronic lymphocytic leukemia (CLL) and their correlation with clinical and genetic classifications. METHODS: All CLL samples sequenced on several versions of OncoPanel, from 2013 to 2022, were examined (n = 209). All variants produced by the next-generation sequencing pipeline, before review, were obtained for these samples. After the...
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