Article
Somatic mutation signatures in primary liver tumors of workers exposed to ionizing radiation.
Scientific reports - 3 Dec 2019
Goerlitz David S, Blancato Jan, Ramesh Archana, Islam Md, Graham Garrett T, Revina Valentina, Kallakury Bhaskar, Zeck Jay, Kirillova Evgeniya, Loffredo Christopher A
Abstract excerpt
Liver cancer is associated with genetic mutations caused by environmental exposures, including occupational exposure to alpha radiation emitted by plutonium. We used whole exome sequencing (WES) to characterize somatic mutations in 3 histologically distinct primary liver tumors (angiosarcoma of the liver (ASL), cholangiocarcinoma (CCA) and hepatocellular carcinoma (HCC)) from Mayak worker subjects occupationally...
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