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Article

Causal Association Between Major Depressive Disorder and Cortical Structure: A Bidirectional Mendelian Randomization Study and Mediation Analysis.

CNS neuroscience & therapeutics - 1 Mar 2025

Zheng Hui, Fang Yong-Jiang, Wang Xiao-Ying, Feng Si-Jia, Tang Tai-Chun, Chen Min

Abstract excerpt

BACKGROUND: Previous observational studies have reported a possible association between major depressive disorder (MDD) and abnormal cortical structure. However, it is unclear whether MDD causes reductions in global cortical thickness (CT) and global area (SA). OBJECTIVE: We aimed to test the bidirectional causal relationship between MDD and CT and SA using a Mendelian randomization (MR) design and performed...

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Cerebral Cortex
TNF gene
Genome-Wide Association Study
Magnetic Resonance Imaging
Major Depressive Disorder

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mediation Analysis

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

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Identifiers

PMID: 40059068
DOI: 10.1111/cns.70319
PMCID: PMC11890974

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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