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Article

Exploring causal association between functional/structural connectivity and major depression disorder: A bidirectional Mendelian randomization study.

Journal of affective disorders - 15 Jan 2025

Liu Huacong, Lai Zhenyi, Huang Yumeng, Liu Zhaoxing, Liu Ying, Cai Xiaowen, Huang Shengtao, Chen Junqi, Huang Yong

Abstract excerpt

OBJECTIVES: Prior observational studies have suggested a correlation between major depressive disorder (MDD) and communication imbalances within the resting-state brain network (RSN), but the causal relationship remains unclear. This research uses Mendelian randomization (MR) analysis to explore the potential causal effects between functional connectivity (FC), structural connectivity (SC) and MDD. METHODS:...

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Brain
Depressive Disorder, Major
Magnetic Resonance Imaging
Mendelian Randomization Analysis
Nerve Net

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 39442706
DOI: 10.1016/j.jad.2024.10.091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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