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Article

Obesity causally influencing brain cortical structure: a Mendelian randomization study.

Cerebral cortex (New York, N.Y. : 1991) - 24 Jul 2023

Chen Wenhui, Feng Jia, Guo Jie, Dong Shiliang, Li Rufeng, Ngo Jacky C K, Wang Cunchuan, Ma Yi, Dong Zhiyong

Abstract excerpt

Obesity may lead to cognitive impairment and psychiatric disorders, which are associated with alterations in the brain cortical structure. However, the exact causality remains inconclusive. We aimed to conduct two-sample Mendelian randomization (MR) analysis to identify the causal associations of obesity [body mass index (BMI), waist-hip ratio (WHR), and waist-hip ratio adjusted for BMI ((WHRadjBMI)) and brain...

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PMID: 37328935
DOI: 10.1093/cercor/bhad214

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