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Article

Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders.

Nature neuroscience - 1 Nov 2022

Guo Jing, Yu Ke, Dong Shan-Shan, Yao Shi, Rong Yu, Wu Hao, Zhang Kun, Jiang Feng, Chen Yi-Xiao, Guo Yan, Yang Tie-Lin

Abstract excerpt

Observational studies have reported the correlations between brain imaging-derived phenotypes (IDPs) and psychiatric disorders; however, whether the relationships are causal is uncertain. We conducted bidirectional two-sample Mendelian randomization (MR) analyses to explore the causalities between 587 reliable IDPs (N = 33,224 individuals) and 10 psychiatric disorders (N = 9,725 to 161,405). We identified nine...

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Causality
Functional Brain Connectivity Studies
Genetic Associations and Epidemiology
Genome-Wide Association Study
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mental Disorders

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PMID: 36216997
DOI: 10.1038/s41593-022-01174-7

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