Association Between Polygenic Risk and Symptom Severity Change After Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder.

doi:10.1002/ajmg.b.33026

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Article

Association Between Polygenic Risk and Symptom Severity Change After Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jul 2025

Bäckman Julia, Wallert John, Halvorsen Matthew, Roelstraete Bjorn, de Schipper Elles, Strom Nora I, Eide Thorstein Olsen, Höffler Kira D, Mattheisen Manuel, Hansen Bjarne, Kvale Gerd, Hagen Kristen, Haavik Jan, Mataix-Cols David, Rück Christian, Crowley James J

Abstract excerpt

A large proportion of patients undergoing cognitive behavior therapy (CBT) for obsessive-compulsive disorder (OCD) do not respond sufficiently to treatment. Identifying predictors for change in symptom severity after treatment could inform clinical decision-making, allow for better-tailored interventions, and avoid treatment failure. Prior research on predictors for treatment response has, however, yielded...

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PMID: 40052195
DOI: 10.1002/ajmg.b.33026
PMCID: PMC12129668

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