Article
Analysis of Archival Sera From Norovirus-Infected Individuals Demonstrates That Cross-Blocking of Emerging Viruses Is Genotype-Specific.
The Journal of infectious diseases - 16 Oct 2024
Pilewski Kelsey A, Ford-Siltz Lauren A, Tohma Kentaro, Kendra Joseph A, Landivar Michael, Parra Gabriel I
Abstract excerpt
BACKGROUND: Rapidly evolving RNA viruses, such as human norovirus, generate extraordinary sequence diversity, posing a significant challenge to vaccine design. This diversity, coupled with short-lasting natural immunity, leads to reinfection throughout one's lifetime. How reexposure shapes humoral immunity to future norovirus strains remains incompletely understood. METHODS: We profiled the antibody responses...
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