Article
Static and Evolving Norovirus Genotypes: Implications for Epidemiology and Immunity.
PLoS pathogens - 1 Jan 2017
Parra Gabriel I, Squires R Burke, Karangwa Consolee K, Johnson Jordan A, Lepore Cara J, Sosnovtsev Stanislav V, Green Kim Y
Abstract excerpt
Noroviruses are major pathogens associated with acute gastroenteritis worldwide. Their RNA genomes are diverse, with two major genogroups (GI and GII) comprised of at least 28 genotypes associated with human disease. To elucidate mechanisms underlying norovirus diversity and evolution, we used a large-scale genomics approach to analyze human norovirus sequences. Comparison of over 2000 nearly full-length ORF2...
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