Article
Immune Imprinting Drives Human Norovirus Potential for Global Spread.
mBio - 26 Oct 2022
Lindesmith Lisa C, Boshier Florencia A T, Brewer-Jensen Paul D, Roy Sunando, Costantini Veronica, Mallory Michael L, Zweigart Mark, May Samantha R, Conrad Helen, O'Reilly Kathleen M, Kelly Daniel, Celma Cristina C, Beard Stuart, Williams Rachel, Tutill Helena J, Becker Dreps Sylvia, Bucardo Filemón, Allen David J, Vinjé Jan, Goldstein Richard A, Breuer Judith, Baric Ralph S
Abstract excerpt
Understanding the complex interactions between virus and host that drive new strain evolution is key to predicting the emergence potential of variants and informing vaccine development. Under our hypothesis, future dominant human norovirus GII.4 variants with critical antigenic properties that allow them to spread are currently circulating undetected, having diverged years earlier. Through large-scale sequencing...
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