Article
Emergence of Novel Human Norovirus GII.17 Strains Correlates With Changes in Blockade Antibody Epitopes.
The Journal of infectious diseases - 5 Dec 2017
Lindesmith Lisa C, Kocher Jacob F, Donaldson Eric F, Debbink Kari, Mallory Michael L, Swann Excel W, Brewer-Jensen Paul D, Baric Ralph S
Abstract excerpt
Background: Human norovirus is a significant public health burden, with >30 genotypes causing endemic levels of disease and strains from the GII.4 genotype causing serial pandemics as the virus evolves new ligand binding and antigenicity features. During 2014-2015, genotype GII.17 cluster IIIb strains emerged as the leading cause of norovirus infection in select global locations. Comparison of capsid sequences...
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