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Donor HLA-DQ genetic and functional divergence affect the control of BK polyoma virus infection after kidney transplantation

5 Mar 2025

Abstract excerpt

BK polyomavirus (BKPyV) infection remains a major concern after kidney transplantation, increasing the risk of graft loss in the absence of specific antiviral agent now available. Here, we investigated the impact of HLA diversity on the control of posttransplant BKPyV replication. High HLA evolutionary divergence (HED) at the DQ locus in the donor was an independent predictor of BKPyV-free outcome. More...

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PMID: 40043107
DOI: 10.1126/sciadv.adt3499

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