Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Donor HLA Class 1 Evolutionary Divergence Is a Major Predictor of Liver Allograft Rejection : A Retrospective Cohort Study.

Annals of internal medicine - 1 Oct 2021

Féray Cyrille, Taupin Jean-Luc, Sebagh Mylène, Allain Vincent, Demir Zeynep, Allard Marc-Antoine, Desterke Christophe, Coilly Audrey, Saliba Faouzi, Vibert Eric, Azoulay Daniel, Guettier Catherine, Chatton Arthur, Debray Dominique, Caillat-Zucman Sophie, Samuel Didier

Abstract excerpt

BACKGROUND: The HLA evolutionary divergence (HED), a continuous metric quantifying the peptidic differences between 2 homologous HLA alleles, reflects the breadth of the immunopeptidome presented to T lymphocytes. OBJECTIVE: To assess the potential effect of donor or recipient HED on liver transplant rejection. DESIGN: Retrospective cohort study. SETTING: Liver transplant units. PATIENTS: 1154 adults and 113...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HLA Antigens
Share to Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biopsy

Share to Evolution, Molecular

Share to Graft Rejection

Share to Liver Transplantation

Share to Time Factors

Source

Identifiers

PMID: 34424731
DOI: 10.7326/M20-7957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Donor HLA Class 1 Evolutionary Divergence Is a Major Predictor of Liver Allograft Rejection : A Retrospective Cohort Study.PMID 34424731Read ↗

Donor HLA class 1 evolutionary divergence and late allograft rejection after liver transplantation in children: An emulated target trialSemantic proximity Read ↗

Impact of HLA evolutionary divergence and donor-recipient molecular mismatches on antibody-mediated rejection of kidney allograftsSemantic proximity Read ↗

Impact of HLA divergence on humoral response to SARS-CoV-2 and HBV vaccines in the liver transplantation settingSemantic proximity Read ↗

Evolutionary divergence and expression of differential HLA alleles between donor and recipient influence acute GVHD onset after allogenetic HSCTSemantic proximity Read ↗

Impact of the HLA Immunopeptidome on Survival of Leukemia Patients After Unrelated Donor TransplantationSemantic proximity Read ↗

Human leukocyte antigen evolutionary divergence influences outcomes of paediatric patients and young adults affected by malignant disorders given allogeneic haematopoietic stem cell transplantation from unrelated donorsSemantic proximity Read ↗

Interindividual HLA Evolutionary Divergence in Single HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation for Malignant Hematological Disorders: A Report on Behalf of the Cellular Therapy and Immunobiology Working Party of the EBMTSemantic proximity Read ↗

Determining the Quantitative Principles of T Cell Response to Antigenic Disparity: The Case of Stem Cell Transplant Donor-Recipient Exome Wide Mismatching and HLA Bound Alloreactive PeptidesSemantic proximity Read ↗

The impact of genome-wide histocompatibility on liver transplantation outcomesSemantic proximity Read ↗

Qualitative, rather than quantitative, differences between HLA-DQ alleles affect HLA-DQ immunogenicity in organ transplantation.Semantic proximity Read ↗

Donor-recipient HLA molecular mismatch and T follicular helper-related genetic variants are associated with dnDSA development after kidney transplantation.Semantic proximity Read ↗

HLA Evolutionary Divergence as a Prognostic Marker for AML Patients Undergoing Allogeneic Stem Cell TransplantationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.