A multicenter kidney transplantation study identifies hierarchy and directionality of HLA-DQ alloimmune responses.

doi:10.1038/s41467-026-76912-7

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Article

A multicenter kidney transplantation study identifies hierarchy and directionality of HLA-DQ alloimmune responses.

Nature communications - 19 Aug 2026

Van Den Broek Dennis A J, Agrawal Akansha, Crespo Marta, Emonds Marie-Paule, Heidt Sebastiaan, van der Helm Danny, Lenz Tobias L, Meneghini Maria, Palou Eduard, Redondo Pachón Dolores, Roelen Dave L, Senev Aleksandar, Naesens Maarten, de Vries Aiko P J, Tambur Anat R

Abstract excerpt

HLA-incompatibility between recipient and donor is conventionally assessed by counting serologic mismatches. More recently, tools quantifying differences at the amino acid level are advocated to prognosticate risk for generation of de-novo donor-specific antibodies (dnDSA). Using hierarchical clustering based on HLA evolutionary divergence and amino acid physiochemical unique qualities to evaluate HLA-DQ...

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Topics

Female
Humans
Male
Alleles
Graft Rejection

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

HLA-DQ Antigens

Immunity, Humoral

Isoantibodies

Kidney Transplantation

Risk Assessment

Phylogeny

Biological Evolution

Source

Open in PubMed Open full text

Identifiers

PMID: 42749717
DOI: 10.1038/s41467-026-76912-7
PMCID: PMC13582852

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