Article
The impact of amino acid variability on alloreactivity defines a functional distance predictive of permissive HLA-DPB1 mismatches in hematopoietic stem cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Feb 2015
Crivello Pietro, Zito Laura, Sizzano Federico, Zino Elisabetta, Maiers Martin, Mulder Arend, Toffalori Cristina, Naldini Luigi, Ciceri Fabio, Vago Luca, Fleischhauer Katharina
Abstract excerpt
A major challenge in unrelated hematopoietic stem cell transplantation (HSCT) is the prediction of permissive HLA mismatches, ie, those associated with lower clinical risks compared to their nonpermissive counterparts. For HLA-DPB1, a clinically prognostic model has been shown to be matching for T cell epitope (TCE) groups assigned by cross reactivity of T cells alloreactive to HLA-DPB1∗09:01; however, the...
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