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Article

Impact of the HLA Immunopeptidome on Survival of Leukemia Patients After Unrelated Donor Transplantation

20 Jan 2023

Abstract excerpt

PURPOSE Immunopeptidome divergence between mismatched HLA-DP is a determinant of T-cell alloreactivity and clinical tolerability after fully HLA-A, -B, -C, -DRB1, -DQB1 matched unrelated donor hematopoietic cell transplantation (UD-HCT). Here, we tested this concept in HLA-A, -B, and -C disparities after single class I HLA-mismatched UD-HCT. PATIENTS AND METHODS We studied 2,391 single class I HLA-mismatched and...

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Identifiers

PMID: 36669145
DOI: 10.1200/jco.22.01229

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