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Article

Ribosomal DNA arrays are the most H-DNA rich element in the human genome.

NAR genomics and bioinformatics - 1 Mar 2025

Chantzi Nikol, Chan Candace S Y, Patsakis Michail, Nayak Akshatha, Montgomery Austin, Mouratidis Ioannis, Georgakopoulos-Soares Ilias

Abstract excerpt

Repetitive DNA sequences can form noncanonical structures such as H-DNA. The new telomere-to-telomere genome assembly for the human genome has eliminated gaps, enabling examination of highly repetitive regions including centromeric and pericentromeric repeats and ribosomal DNA arrays. We find that H-DNA appears once every 25 000 base pairs in the human genome. Its distribution is highly inhomogeneous with H-DNA...

Read the complete abstract on PubMed

Topics

Humans
Genome, Human
DNA, Ribosomal
Histone-Lysine N-Methyltransferase
Alleles
Binding Sites

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Nucleotide Motifs

Repetitive Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 40041207
DOI: 10.1093/nargab/lqaf012
PMCID: PMC11879447

Genes

PRDM9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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