Article

The conservation landscape of the human ribosomal RNA gene repeats

2018-04-28

Abstract excerpt

<h4>ABSTRACT</h4> Ribosomal RNA gene repeats (rDNA) encode ribosomal RNA, a major component of ribosomes. Ribosome biogenesis is central to cellular metabolic regulation, and several diseases are associated with rDNA dysfunction, notably cancer, However, its highly repetitive nature has severely limited characterization of the elements responsible for rDNA function. Here we make use of phylogenetic footprinting t...

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Literature Corpus work: df8c3b41-a623-5fe5-a88f-2324dc97748b
DOI: 10.1101/242602

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