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Article

Two DRB3 residues predictively associate with the progression to type 1 diabetes among DR3 carriers.

JCI insight - 4 Mar 2025

Zhao Lue Ping, Papadopoulos George K, Skyler Jay S, Kwok William W, Bondinas George P, Moustakas Antonis K, Wang Ruihan, Pyo Chul-Woo, Nelson Wyatt C, Geraghty Daniel E, Lernmark Åke

Abstract excerpt

HLA-DR genes are associated with the progression from stage 1 and stage 2 to onset of stage 3 type 1 diabetes (T1D), after accounting HLA-DQ genes with which they are in high linkage disequilibrium. Based on an integrated cohort of participants from 2 completed clinical trials, this investigation finds that, sharing a haplotype with the DRB1*03:01 (DR3) allele, DRB3*01:01:02 and *02:02:01 have respectively...

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Adolescent
Child
Diabetes Mellitus, Type 1
Disease Progression
Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DRB1 Chains

HLA-DRB3 Chains

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Identifiers

PMID: 40036070
DOI: 10.1172/jci.insight.184348
PMCID: PMC11981622

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