HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression.

doi:10.2337/db15-1105

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Article

HLA-DRB115:01-DQA101:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression.

Diabetes - 1 Apr 2016

Pugliese Alberto, Boulware David, Yu Liping, Babu Sunanda, Steck Andrea K, Becker Dorothy, Rodriguez Henry, DiMeglio Linda, Evans-Molina Carmella, Harrison Leonard C, Schatz Desmond, Palmer Jerry P, Greenbaum Carla, Eisenbarth George S, Sosenko Jay M

Abstract excerpt

The HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 haplotype is linked to protection from the development of type 1 diabetes (T1D). However, it is not known at which stages in the natural history of T1D development this haplotype affords protection. We examined a cohort of 3,358 autoantibody-positive relatives of T1D patients in the Pathway to Prevention (PTP) Study of the Type 1 Diabetes TrialNet. The PTP study examines...

Topics

Adolescent
Adult
Autoantibodies
Child
Child, Preschool
Diabetes Complications
Diabetes Mellitus, Type 1
Disease Progression
Family

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Genetic Predisposition to Disease

HLA-DQ alpha-Chains

HLA-DQ beta-Chains

HLA-DRB1 Chains

Haplotypes

Humans

Male

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 26822082
DOI: 10.2337/db15-1105
PMCID: PMC4806662

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