Article
Type 1 diabetes in the Spanish population: additional factors to class II HLA-DR3 and -DR4.
BMC genomics - 20 Apr 2005
Urcelay Elena, Santiago José L, de la Calle Hermenegildo, Martínez Alfonso, Méndez Julián, Ibarra José M, Maluenda Carlos, Fernández-Arquero Miguel, de la Concha Emilio G
Abstract excerpt
BACKGROUND: The Major Histocompatibility Complex is the main genetic contributor to susceptibility to type 1 diabetes (T1D); genome-wide scans have consistently mapped increased predisposition to this region. The highest disease risk has been associated with HLA-DR3 and HLA-DR4. In particular, the DR3-positive ancestral haplotype 18.2 was reported as highly diabetogenic. We aimed to corroborate whether this...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Case-Control Studies
- Child
- Child, Preschool
- Cohort Studies
- Diabetes Mellitus, Type 1
- Female
- Genetic Predisposition to Disease
- Genotype
- HLA-DR3 Antigen
- HLA-DR4 Antigen