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Article

Type 1 diabetes in the Spanish population: additional factors to class II HLA-DR3 and -DR4.

BMC genomics - 20 Apr 2005

Urcelay Elena, Santiago José L, de la Calle Hermenegildo, Martínez Alfonso, Méndez Julián, Ibarra José M, Maluenda Carlos, Fernández-Arquero Miguel, de la Concha Emilio G

Abstract excerpt

BACKGROUND: The Major Histocompatibility Complex is the main genetic contributor to susceptibility to type 1 diabetes (T1D); genome-wide scans have consistently mapped increased predisposition to this region. The highest disease risk has been associated with HLA-DR3 and HLA-DR4. In particular, the DR3-positive ancestral haplotype 18.2 was reported as highly diabetogenic. We aimed to corroborate whether this...

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PMID: 15842729
DOI: 10.1186/1471-2164-6-56
PMCID: PMC1097726

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